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The traditional Indian medicine, herb Salacia oblonga may help treat diabetes Posted By: Medical News Medicine Study News Published: Tuesday, 8-Feb-2005 Printer Friendly Email to a friend:::: Herbs used in traditional medicine India to treat diabetes seems to lower blood sugar and insulin levels in a manner similar to prescription drugs, reports a new study. Researchers gave extracts of the herb Salacia oblonga to 39 healthy adults, and the results were promising. The largest dose of the herb extract – 1,000 mg – decreased insulin levels and blood glucose by 29 and 23 percent respectively. :: "This kind of reductions are similar to what we might see with prescription drugs orally for people with diabetes, "said Steve Hertzler, co-author and assistant professor of nutrition at Ohio State University.:: Salacia oblonga, that is native to regions of India and Sri Lanka, binds to intestinal enzymes that break down carbohydrates in the body. These enzymes, called alpha-glucosidases, turn carbohydrates into glucose, the sugar that circulates throughout the body. If the enzyme binds to the herbal extract rather than a carbohydrate, then less glucose gets into the bloodstream blood, resulting in low blood sugar and insulin levels. :: "Lowering blood glucose levels in the blood reduces the risk of diseases complications in people with diabetes, "Hertzler said." Also, poor compliance with diabetes medications often hinders the effectiveness of these drugs. It may be easier to get someone to take an herb with food or drink, compared with a pill. ":: The study appears in a number recent Journal of the American Dietetic Association. :: Thirty-nine healthy adults participated in four test meal tolerance separately. These meals, which occurred in beverage form, were separated from three to 14 days apart. Each participant fasted for at least 10 hours before consuming the test beverage. :: Participants were asked equivalent to drinking about two cups' cold beverage containing zero, 500, 700 or 1,000 milligrams of Salacia oblonga extract. Then the researchers used the finger prick method to draw blood samples from each person every 15 to 30 minutes for three hours. These blood samples were used to determine concentrations of insulin and blood glucose. The biggest changes in blood glucose and insulin levels usually happen within the first two hours after eating. :: The beverage that contains the greater concentration of herbal extract – 1,000 milligrams – provided the most dramatic reduction in insulin blood glucose levels. Insulin levels were 29 percent lower, while levels of glucose in the blood were 23 percent lower compared with the control beverage, which contained no herbal extract. :: As Salacia oblonga can cause intestinal gas, the researchers had the study participants in the breath hydrogen samples hourly for eight hours after drinking the test beverage. The participants collected their breath in plastic tubes. The researchers analyzed the breath samples for hydrogen and methane content – the level of either substance in the breath corresponds to the level of content in the colon. :: The subjects also rated the frequency and severity of nausea, abdominal cramps and bloating and gas for two days after consumption of each test meal. :: While the test beverages containing Salacia oblonga caused an increase in hydrogen excretion breath, reports of gastrointestinal discomfort were minimal, Hertzler said. :: Now he and his colleagues are trying to find out what dose of the herb is more effective, and when they should take in relation to a meal.:: "We want to know how long it takes for the herb to bind to enzymes that degrade carbohydrates carbon, "Hertzler said." Participants in this study took the herb with their meal, but maybe taking it before eating would be even more effective .:: The researchers also want to study the effects of Salacia oblonga in people with diabetes.:: "A lot of studies show that reductions levels of blood sugar reduces the risk for all types of diabetes-related complications such as kidney disease and nerve and eye damage "Hertzler said." We want to see if this herb has this kind of effect. ":: Salacia oblonga is relatively rare in the United States, Hertzler said that although there are manufacturers that sell the herb through the Internet.:: This study was supported by Ross Products Division of Abbott Laboratories in Columbus. :: Hertzler continues to conduct Salacia oblonga studies with the Ross Products Division of Abbott Laboratories. He has no links with the company beyond this affiliation. :: Hertzler conducted the work with former Ohio State colleague Patricia Heacock, who is now at Rutgers, The State University of New Jersey, Jennifer Williams, a scientist clinical Ross Products Division, Abbott Laboratories, and Bryan Wolf, former research scientists with Ross Products Division
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